Advisor/Senior Advisor, ADC Conjugation

Company: Eli Lilly and Company
Location: Indianapolis
Posted on: June 24, 2025

Job Description:

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. Overview: At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism. Position Summary: Bioprocess Innovation team has an exciting opportunity for an innovative individual to join our organization and develop the growing oncology portfolio of antibody-drug conjugates. The Advisor/Senior Advisor, ADC Conjugation will collaborate on phase appropriate bioconjugation process development and manufacturing efforts including optimization, characterization, and validation of the bioconjugation process for oncology programs. Responsibilities: Work in a team environment to drive and manage bioconjugation development and manufacturing activities in-house and at third-party partners for assigned projects. Partner with colleagues in process development and analytical sciences to develop integrated clinical process and manufacturing solutions that achieve quality by design targets with robust control strategies. Partner closely with colleagues in ADC Discovery to enable and advance new bioconjugates from preclinical stages to clinical entry Develop the clinical stage/scale bioconjugation strategy and prepare to and/or enable registration/commercial stage/scale. Provide technical and scientific direction to third-party partners. Create written development instructions and work with third-party partners to perform desired experiments incorporating Quality by Design (QbD). Oversee the preparation of technical reports, data summaries and CMC related documents required for various regulatory submissions. Collaborate on product characterization/comparability and lot release studies. Write and review sections in regulatory submission documents (e.g., IND, IMPD, BLA). Key member of the interdisciplinary CMC project teams. Basic Requirements : Ph.D. in chemistry, biochemistry, or similar field with 0–2 years of experience working in a Biotech or Pharmaceutical FDA regulated industry or an equivalent combination of education, training and/or experience from which comparable knowledge, skills and abilities have been attained. Strong background in hands on bioconjugation activities at lab and/or larger scale. Strong background and experience with novel conjugation chemistries, including but not limited to native cysteine/lysine conjugation, enzymatic, site-specific, and engineered cysteine conjugations Additional Preferences: Experience with antibody drug-conjugate (ADC) modalities is a plus. Experience with manufacturing including strong scientific and technical experience within relevant manufacturing process technologies and unit operations. Experience characterizing conjugation processes using Quality by Design (QbD) principles. Knowledge of structured methodologies for process design, scale-up/down models, process control strategies, and process validation. Knowledge of regulatory environment (ICH/FDA/EMA regulations) and experience with organizing and writing regulatory submissions. Experience writing and presenting clearly on CMC topics. Demonstrable ability to work proactively, independently, and tenaciously. Additional Information: Physical Demands/Travel: The physical demands of this job are consistent with a lab and office environment with 10% travel . The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Work Environment: This position’s work environment is in a lab and office setting. The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job. *To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups. Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $133,500 - $217,800 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. WeAreLilly

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